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Lansoprazole ( ; INN) is a proton-pump inhibitor (PPI) which inhibits the stomach's production of gastric acids. It is manufactured by a number of companies worldwide under several brand names. In the United States, it was first approved by the Food and Drug Administration (FDA) in 1995.〔(Mosby's Drug Consult: Lansoprazole )〕 Prevacid patent protection expired on November 10, 2009.〔(Prevacid drug patents )〕〔(Teva to release Prevacid version when patent expires )〕 Since 2009, lansoprazole has been available over the counter (OTC) in the U.S. in a 15-mg dose marketed by Novartis as Prevacid 24HR.〔 〕〔 〕〔 〕 In Australia, it is marketed by Pfizer as Zoton. Lansoprazole is a proton-pump inhibitor (PPI) in the same pharmacologic class as omeprazole. Lansoprazole has been marketed for many years and is one of several PPIs available.〔http://www.patient.co.uk/showdoc/30002943/〕 It is a racemic 1:1 mixture of the enantiomers dexlansoprazole (Dexilant, formerly named Kapidex) and levolansoprazole.〔(【引用サイトリンク】url=http://epharmacytechnicanschools.com/pharmacy-benefit-update/ )〕 Dexlansoprazole is an enantiomerically pure active ingredient of a commercial drug as a result of the ''enantiomeric shift''. Lansoprazole's plasma elimination half-life (1.5 h) is not proportional to the duration of the drug's effects to the person (i.e. gastric acid suppression). and the effects of the drug last for over 24 hours after it has been used for a day or more.〔 Lansoprazole, 30-mg administered nasogastrically, effectively controls intragastric pH and is an alternative to intravenous pantoprazole in patients who are unable to swallow solid-dose formulations.〔(Effects on 24-Hour Intragastric pH )〕 ==Indications== Lansoprazole is indicated for treatment of: * Ulcers of the stomach and duodenum, and NSAID-induced ulcers * ''Helicobacter pylori'' infection, alongside antibiotics (adjunctive treatment), treatment to kill ''H. pylori'' causing ulcers or other problems involves using two other drugs besides lansoprazole known as "triple therapy", and involves taking twice daily for 10 or 14 days lansoprazole 30-mg, amoxicillin 1,000-mg, and clarithromycin 500-mg * Gastroesophageal reflux disease * Zollinger-Ellison syndrome〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Lansoprazole」の詳細全文を読む スポンサード リンク
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