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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Lasmiditan ： ウィキペディア英語版 Lasmiditan Lasmiditan (codenamed COL-144) is an investigational drug for the treatment of acute migraine. It was discovered by Eli Lilly and Company and is being developed by CoLucid Pharmaceuticals. Phase II clinical trial for dose finding purposes were completed in 2007 for an intravenous〔 and in early 2010 for an oral application form.〔 ==Mechanism of action== Lasmiditan is a serotonin receptor agonist that, like the unsuccessful LY-334,370, selectively binds to the 5-HT1F receptor subtype. A number of triptans have been shown to act on this subtype as well, but only after their affinity for 5-HT1B and 5-HT1D has been made responsible for their anti-migraine activity. The lack of affinity for these receptors might result in fewer side-effects related to vasoconstriction compared to triptans.〔 A 1998 review has found such side-effects to rarely occur in patients taking triptans, but they are contraindicated for patients with ischaemic heart disease, Raynaud's phenomenon or after a myocardial infarction.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Lasmiditan」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.