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Lerisetron
Lerisetron (F-0930-RS) is a drug which acts as an antagonist at the 5HT3 receptor〔Orjales A, Mosquera R, Labeaga L, Rodes R. New 2-piperazinylbenzimidazole derivatives as 5-HT3 antagonists. Synthesis and pharmacological evaluation. ''Journal of Medicinal Chemistry''. 1997 Feb 14;40(4):586-93. PMID 9046349〕 It is a potent antiemetic〔Gomez-de-Segura IA, Grande AG, De Miguel E. Antiemetic effects of Lerisetron in radiation-induced emesis in the dog. ''Acta Oncologica''. 1998;37(7-8):759-63. PMID 10050999〕〔Cooper M, Sologuren A, Valiente R, Smith J. Effects of lerisetron, a new 5-HT3 receptor antagonist, on ipecacuanha-induced emesis in healthy volunteers. ''Arzneimittelforschung''. 2002;52(9):689-94. PMID 12404884〕 and is currently in clinical trials for the treatment of nausea associated with cancer chemotherapy.〔Huckle R. Lerisetron. FAES. ''Current Opinion in Investigational Drugs''. 2003 Jul;4(7):874-7. PMID 14619411〕 == References ==
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