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Levomoramide : ウィキペディア英語版
Levomoramide

Levomoramide is the inactive isomer of the opioid analgesic dextromoramide, invented by the chemist Paul Janssen in 1956. Unlike dextromoramide, which is a potent analgesic with high abuse potential, levomoramide is virtually without activity.〔Janssen PA. ''Journal of the American Chemical Society''. 1956;78:3862.〕〔Janssen PA, Jagenau AM. ''Journal of Pharmacy and Pharmacology'' 1957;9:381.〕
"Resolution reveals that the analgetic activity in this case resides almost entirely in the (+) isomer."〔Daniel Lednicer. Central Analgetics. (1982), p194. ISBN 0-471-08314-3〕
"In the α-CH3 series, one of the optical isomers of each enantiomorphic pair is about twice as active as the racemic mixture; the other isomer is devoid of significant analgesic activity."〔Paul A J Janssen. Synthetic Analgesics Part 1: Diphenylpropylamines. Pergamon Press 1960. p143.〕
However, despite being inactive, levomoramide is scheduled by UN Single Convention on Narcotic Drugs.
==References==


pl:Moramid

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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