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Lipoflavonoid
Lipoflavonoid (or Lipo-flavonoid) is a proprietary, over-the-counter, dietary supplement formula created in 1961, by NUMARK Laboratories, which is claimed by the manufacturer to improve circulation in the inner ear,〔(【引用サイトリンク】url=http://www.fda.gov/ohrms/dockets/dailys/04/mar04/031204/97s-0162-let13227-vol108.pdf )〕 as a means of combatting tinnitus (ringing in the ears).〔("About Lipo-flavonoid: References" ), manufacturers website〕 While it has not been expressly approved by the Food and Drug Administration for this purpose, the formulation and package claims comply with FDA regulations for dietary supplements.〔(【引用サイトリンク】url=http://www.fda.gov/Food/Dietarysupplements/default.htm )〕
Lipoflavonoid is currently being marketed on the Internet and in television commercials specifically to relieve tinnitus.〔("Lipo-flavonoid Testimonials and Reviews" ), manufacturers website〕 Clinical studies of the product appearing in refereed journals address its use in treating sensorineural hearing loss,〔("About Lipo-flavonoid: References" ), manufacturers website〕 both inclusive of and exclusive of Meniere’s disease,〔("Bioflavonoid Therapy in Sensorineural Hearing Loss: A Double-Blind Study", James E. Creston, Marion R. Gillespie, Alvin L. Larson, Arch Otolaryngol. 1965;82(2):159-165 )〕 of which tinnitus is a recognized symptom.〔(【引用サイトリンク】url=http://www.mayoclinic.org/diseases-conditions/menieres-disease/basics/definition/con-20028251 )〕 While a Mayo Clinic article on tinnitus states there is "little evidence that alternative medicine treatments work for tinnitus," the same article goes on to specifically name Lipoflavonoid as an alternative therapy.〔("Tinnitus: Alternative Medicine" )〕 In the early 1960s, the Audiology Center of Walter Reed Hospital conducted a double-blind, placebo-controlled study of the effects of the lemon bioflavonoid active ingredient of Lipo-flavonoid on patients with hearing loss not associated with Meniere's Disease. None of the study participants who took bioflavonoid showed improvement of hearing as measured by pure tone audiometry.〔
==Composition and effects==
Lipoflavonoid is sold as a dietary supplement. It is composed of eriodictyol glycoside (a bioflavonoid found naturally in the peel of lemons) and the following vitamins: vitamin B6 and B12 (B complex), vitamin C, niacin, riboflavin, thiamine, choline, inositol, and pantothenic acid.〔("About Lipo-flavonoid: Lipo-flavonoid-Plus Ingredients" ), manufacturers website〕
Consumer testimonials claim that lipoflavonoid relieves the symptoms of tinnitus.〔(【引用サイトリンク】url=http://www.webmd.com/drugs/drugreview-151683-Lipo-Flavonoid+Plus+Oral.aspx?drugid=151683&drugname=Lipo-Flavonoid+Plus+Oral )〕〔(【引用サイトリンク】url=http://www.amazon.com/DSE-Healthcare-Solutions-LipoFlavonoid-Strength/product-reviews/B000NP9QMK )〕 However, few clinical studies have been performed, and the studies that have been completed have not shown significant efficacy of the product. 〔(【引用サイトリンク】url=http://www.tinnitusformula.com/library/lipoflavonoid-tinnitus/#.U-ZelGK9KK0" )〕 A search of MEDLINE, the National Institutes of Medicine database, did not locate a single clinical study on Lipoflavonoid. 〔(【引用サイトリンク】url=http://www.ncbi.nlm.nih.gov/pubmed/?term=lipoflavonoid" )〕
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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