翻訳と辞書 Words near each other ・ Lipoplatin ・ Lipopolysaccharide ・ Lipopolysaccharide 3-alpha-galactosyltransferase ・ Lipopolysaccharide binding protein ・ Lipopolysaccharide glucosyltransferase I ・ Lipopolysaccharide glucosyltransferase II ・ Lipopolysaccharide kinase (Kdo/WaaP) family ・ Lipopolysaccharide N-acetylglucosaminyltransferase ・ Lipopolysaccharide N-acetylmannosaminouronosyltransferase ・ Lipopolysaccharide-transporting ATPase ・ LipoProfile ・ Lipoprotein ・ Lipoprotein lipase ・ Lipoprotein lipase deficiency ・ Lipoprotein receptor-related protein ・ Lipoprotein(a) ・ Lipoprotein-associated phospholipase A2 ・ Lipoprotein-X ・ Lipoptena ・ Lipoptena cervi ・ Lipoptena depressa ・ Lipoptena mazamae ・ Lipopteninae ・ Lipopterichthys carrioni ・ Lipopterocis ・ Liposarcoma ・ Liposcelididae ・ Liposcelis bostrychophila ・ Liposchema ・ Liposomal daunorubicin Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Lipoprotein(a) ： ウィキペディア英語版 Lipoprotein(a) Lipoprotein(a) (also called Lp(a) or LPA) is a lipoprotein subclass. Genetic studies and numerous epidemiologic studies have identified Lp(a) as a risk factor for atherosclerotic diseases such as coronary heart disease and stroke.〔 Lipoprotein(a) was discovered in 1963 by Kåre Berg and the human gene encoding apolipoprotein(a) was cloned in 1987. == Structure == Lipoprotein(a) () consists of an LDL-like particle and the specific apolipoprotein(a) (), which is covalently bound to the apoB of the LDL like particle. Lp(a) plasma concentrations are highly heritable and mainly controlled by the apolipoprotein(a) gene () located on chromosome 6q26-27. Apo(a) proteins vary in size due to a size polymorphism (VNTR ), which is caused by a variable number of so-called kringle IV repeats in the LPA gene. This size variation at the gene level is expressed on the protein level as well, resulting in apo(a) proteins with 10 to > 50 kringle IV repeats (each of the variable kringle IV consists of 114 amino acids).〔 These variable apo(a) sizes are known as "apo(a) isoforms". There is a general inverse correlation between the size of the apo(a) isoform and the Lp(a) plasma concentration One theory for the size/plasma level correlation involves difference rates of protein synthesis. There appears to be a relationship between the number of kringle repeats and the processing time of the precursor apo (a) protein. That is, the larger the isoform, the more apo(a) precursor protein accumulates intracellularly in the endoplasmic reticulum. Lipoprotein (a) is not fully synthesized until the precursor protein is released from the cell, so the slower rate of production for the larger isoforms limits the plasma concentration. Apo(a) is expressed by liver cells (hepatocytes), and the assembly of apo(a) and LDL particles seems to take place at the outer hepatocyte surface. The half-life of Lp(a) in the circulation is about 3 to 4 days. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Lipoprotein(a)」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.