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Lofendazam〔DE Patent 1929656〕 is an organic molecule which is a benzodiazepine derivative. Lofendazam is a 1,5-benzodiazepine, with the nitrogen atoms located at positions 1 and 5 of the diazepine ring; therefore, lofendazam is most closely related to other 1,5-benzodiazepines such as clobazam. 〔Malik F, Hasan M, Khan KM, Perveen S, Snatzke G, Duddeck H, Voelter W. Syntheses and CD studies of optically active substituted 1,3,4,5-tetrahydro- 2H-1,5-benzodiazepin- 2-ones. ''Liebigs Annalen der Chemie'', 1995. (10):1861-1869.〕〔Aversa MC, Giannetto P, Romeo G, Ficarra P, Vigorita MG. Nuclear magnetic resonance spectra of psychotherapeutic agents. V * - conformational analysis of 1,3,4,5-tetrahydro- 2H-1,5-benzodiazepin- 2-ones. ''Organic Magnetic Resonance'', 1981. 15(4):394-398〕 Lofendazam as a human pharmaceutical has sedative and anxiolytic effects similar to those produced by other benzodiazepine derivatives. It is an active metabolite of another benzodiazepine, arfendazam.〔J. Adrien, F. Albani, A. Baruzzi, M. Berger, E.O. Bixler, A.A. Borbeley, D.G. Dikeos, R. Drucker-Colin, R. Fritsch Montero, Y. Hishikawa, S. Inoue, A. Kales, E. Lugaresi, H. Merchant-Nancy, J.M. Monti. ''The Pharmacology of Sleep''. Springer. ISBN 978-3-540-58961-7〕 ==See also== *Benzodiazepine *Arfendazam *Clobazam 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Lofendazam」の詳細全文を読む スポンサード リンク
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