翻訳と辞書 Words near each other ・ Lore Lindu National Park ・ Lore Lorentz ・ Lore Noto ・ Lore of the Witch World ・ Lore Segal ・ Lore Sjöberg ・ Lorea ・ Lorea Canales ・ Loreak ・ Loreal pit ・ Loreauville High School ・ Loreauville, Louisiana ・ Loreburn ・ Loreburn Report ・ Loreburn, Saskatchewan ・ Loreclezole ・ Loredan ・ Loredan Popa ・ Loredana ・ Loredana Auletta ・ Loredana Berté ・ Loredana Boboc ・ Loredana Cannata ・ Loredana Dinu ・ Loredana Errore ・ Loredana Groza ・ Loredana Lecciso ・ Loredana Marcello ・ Loredana Nusciak ・ Loredana Sparano Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Loreclezole ： ウィキペディア英語版 Loreclezole Loreclezole is a sedative and an anticonvulsant which acts as a GABAA receptor positive allosteric modulator. The binding site of loreclezole has been shown experimentally to be shared by valerenic acid, an extract of the root of the valerian plant. Structurally, loreclezole is a triazole derivative. In animal seizure models, loreclezole is protective against pentylenetetrazol seizures but is less active in the maximal electroshock test. In addition, at low, nontoxic doses, the drug has anti-absence activity in a genetic model of generalized absence epilepsy. Consequently, loreclezole has a profile of activity similar to that of benzodiazepines. A potential benzodiazepine-like interaction with GABA receptors is suggested by the observation that the anticonvulsant effects of loreclezole can be reversed by benzodiazepine receptor inverse agonists. The benzodiazepine antagonist flumazenil, however, fails to alter the anticonvulsant activity of loreclezole, indicating that loreclezole is not a benzodiazepine receptor agonist. Using native rat and cloned human GABA-A receptors, loreclezole strongly potentiated GABA-activated chloride current. However, activity of the drug did not require the presence of the γ-subunit and was not blocked by flumazenil, confirming that loreclezole does not interact with the benzodiazepine recognition site. ==References== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Loreclezole」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.