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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Lorglumide ： ウィキペディア英語版 Lorglumide Lorglumide (CR-1409) is a drug which inhibits gastrointestinal motility and reduces gastric secretions, acting as a cholecystokinin antagonist,〔Makovec F, Bani M, Cereda R, Chisté R, Pacini MA, Revel L, Rovati LA, Rovati LC, Setnikar I. Pharmacological properties of lorglumide as a member of a new class of cholecystokinin antagonists. ''Arzneimittelforschung''. 1987 Nov;37(11):1265-8. PMID 3440035〕 with fairly high selectivity for the CCKA subtype.〔González-Puga C, García-Navarro A, Escames G, León J, López-Cantarero M, Ros E, Acuña-Castroviejo D. Selective CCK-A but not CCK-B receptor antagonists inhibit HT-29 cell proliferation: synergism with pharmacological levels of melatonin. ''Journal of Pineal Research''. 2005 Oct;39(3):243-50. PMID 16150104〕 It has been suggested as a potential treatment for a variety of gastrointestinal problems including stomach ulcers, irritable bowel syndrome, dyspepsia, constipation and pancreatitis, as well as some forms of cancer, but animal and human testing has produced inconsistent results and no clear therapeutic role has been established, although it is widely used in scientific research.〔de Tullio P, Delarge J, Pirotte B. Recent advances in the chemistry of cholecystokinin receptor ligands (agonists and antagonists). ''Current Medicinal Chemistry''. 1999 Jun;6(6):433-55. PMID 10213792〕〔de Tullio P, Delarge J, Pirotte B. Therapeutic and chemical developments of cholecystokinin receptor ligands. ''Expert Opinion on Investigational Drugs''. 2000 Jan;9(1):129-46. PMID 11060666〕〔Herranz R. Cholecystokinin antagonists: pharmacological and therapeutic potential. ''Medical Research Reviews''. 2003 Sep;23(5):559-605. PMID 12789687〕〔Berna MJ, Tapia JA, Sancho V, Jensen RT. Progress in developing cholecystokinin (CCK)/gastrin receptor ligands that have therapeutic potential. ''Current Opinion in Pharmacology''. 2007 Dec;7(6):583-92. PMID 17997137〕 ==Synthesis== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Lorglumide」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.