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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Losigamone ： ウィキペディア英語版 Losigamone Losigamone is an investigational drug for the treatment of epilepsy. It has been studied as an add-on treatment for partial seizures.〔 Phase III clinical trials were conducted around the year 2000.〔 ==Mechanism of action== The mechanism of action is not known. Data regarding the interaction of losigamone with GABA receptors are inconsistent: it increases GABA-induced chloride influx in spinal cord neuron cultures, but has no significant influence on GABAergic inhibitory postsynaptic potentials in hippocampal slices.〔 Interaction with potassium〔 and sodium channels〔 has been proposed. Results from both in vitro and in vivo experiments confirm that the pharmacological activity profiles of the two losigamone enantiomers are not identical and suggest further that excitatory amino acid-mediated processes are involved in the mode of action of (+)-losigamone (the compound shown in the image) whereas (–)-losigamone does not possess such properties.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Losigamone」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.