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・ Lumiracoxib
・ Lumirioxa
・ Lumirubin
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・ Lumi River (Zambia)
・ Lumi, Yemen
・ Lumia
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Lumican
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Lumican : ウィキペディア英語版
Lumican

Lumican, also known as LUM, is an extracellular matrix protein that, in humans, is encoded by the ''LUM'' gene on chromosome 12.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4060 )
== Structure ==

Lumican is a proteoglycan Class II member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin.

Like the other SLRPs, lumican has a molecular weight of about 40 kiloDaltons and has four major intramolecular domains:
#a signal peptide of 16 amino acid residues;
#a negatively-charged N-terminal domain containing sulfated tyrosine and disulfide bond(s);
#ten tandem leucine-rich repeats allowing lumican to bind to other extracellular components such as collagen;
#a carboxyl terminal domain of 50 amino acid residues containing two conserved cysteines 32 residues apart.
There are four N-linked sites within the leucine-rich repeat domain of the protein core that can be substituted with keratan sulfate. The core protein of lumican (like decorin and fibromodulin) is horseshoe shaped. This enables it bind to collagen molecules within a collagen fibril, thus helping keep adjacent fibrils apart.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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