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Lymphangiectasia : ウィキペディア英語版 | Lymphangiectasia
Lymphangiectasia is a pathologic dilation of lymph vessels.〔McGavin/ Zachary (2007), Pathologic Basis of Veterinary Disease〕 When it occurs in the intestines of dogs, and more rarely humans, it causes a disease known as "intestinal lymphangiectasia."〔 This disease is characterized by lymphatic vessel dilation, chronic diarrhea and loss of proteins such as serum albumin and globulin. It is considered to be a chronic form of protein-losing enteropathy. It is also known as "lymphangiectasis". ==Cause== Biopsy of the small intestine shows dilation of the lacteals of the villi and distension of the lymphatic vessels. Reduced lymph flow leads to a malabsorption syndrome of the small intestine, especially of fat and fat-soluble vitamins. Rupture of the lymphatics causes protein loss into the intestines. The most common cause of lymphangiectasia was congenital malformation of the lymphatics. Secondary lymphangiectasia may be caused by granulomas or cancer causing lymphatic obstruction, or increased central venous pressure (CVP) causing abnormal lymph drainage. Increased CVP can be caused by pericarditis or right-sided heart failure. Inflammatory bowel disease can also lead to inflammation of the lymphatics and lymphangiectasia through migration of inflammatory cells through the lymphatics.
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