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Lysophosphatidylcholines (LPC, lysoPC), also called lysolecithins, are a class of chemical compounds which are derived from phosphatidylcholines. They result from partial hydrolysis of phosphatidylcholines, which removes one of the fatty acid groups. The hydrolysis is generally the result of the enzymatic action of phospholipase A2.〔(Phosphatidylcholine and related lipids ), lipidlibrary.co.uk〕 Among other properties, they stimulate phagocyte recruitment when released by apoptotic cells. Moreover, LPCs can be used in the lab to cause demyelination of brain slices, to mimic the effects of demyelinating diseases such as multiple sclerosis. Further, they are known to stimulate phagocytosis of the myelin sheath and can change the surface properties of erythrocytes.〔 LPC-induced demyelination is thought to occur through the actions of recruited macrophages and microglia which phagocytose nearby myelin. Invading T cells are also thought to mediate this process. Bacteria such as Legionella pneumophila utilize phospholipase A2 end-products ( fatty acids and lysophospholipids) to cause host cell (macrophage) apoptosis through cytochrome C release. LPCs are present as minor phospholipids in the cell membrane (≤ 3%) and in the blood plasma (8-12%).〔 Since LPCs are quickly metabolized by lysophospholipase and LPC-acyltransferase, they last only shortly ''in vivo''. By replacing the acyl-group within the LPC with an alkyl-group, alkyl-lysophospholipids (ALP) were synthesized. These LPC analogues are metabolically stable, and several such as edelfosine, miltefosine and perifosine are under research and development as drugs against cancer and other diseases. Lysophosphatidylcholine processing has been discovered to be an essential component of normal human brain development, those born with genes that prevent adequate uptake suffer from lethal microcephaly. LPCs occur in many foods naturally. In Starch: Chemistry and Technology third edition on page 592, the authors cite that “lysophosphatidylcholine makes up about 70% of the lipids in oat starch.” 〔(【引用サイトリンク】title=Starch )〕 Their anti-cancer abilities are special since they do not target the cell DNA but insert into the plasma membrane and cause apoptosis through influencing several signal pathways. Therefore their effects are independent of the proliferation state of the tumor cell. Other Names for Phosphatidylcholine in Food, Products, and Industry Lysolecithin is a name used prior to the 1980s that was lost and now is found as lysophosphatidylcholine. In addition to several other names lysolecithin / lysophosphatidylcholine is also called hydrolyzed lecithin or hydrolysed lecithin or enzyme-modified lecithin. It is often shortened to LPC or lysoPC. The demyelinating effects of lysolecithin / lysophosphatidylcholine occur through topical application 〔(【引用サイトリンク】title=Schwann cell proliferation following lysolecithin-induced demyelination. )〕 and injection.〔(【引用サイトリンク】title=Multiple Sclerosis Research: Research: Promoting remyelination is not a simple task )〕 Lysophosphatidylcholine could be the lost link in the Multiple Sclerosis controversy between the neurologists and the vascular surgeons since lysophosphatidylcholine has a twofold inflammation effect - lysophosphatidylcholine causes lesions on the central nervous system 〔http://www.jneurosci.org/content/18/7/2498.full.pdf〕 and lysophosphatidylcholine causes vasoconstriction in the venous system.〔(【引用サイトリンク】title=Kidney International - Abstract of article: Endothelial function in proteinuric renal disease )〕 More is discussed below concerning possible diseases related to excessive intake of lysophosphatidylcholine. If one has sclerosis or venous occlusion then one may want to try removing all sources of lysophosphatidylcholine as seen in these foods and products. In the Biochemistry of Foods, Peter Eck explains recombinant DNA technologies in food. Pages 543-545 explain the use of glycerophospholipid cholesterol acyltransferase and the reaction products which are lysophospholipids. He states that “the enzyme preparation is used in egg yolk and whole eggs, in processed meats, in degumming of vegetable oils, in milk products such as cheese, and in bakery products containing eggs, such as cake products.” Then he lists each one and that in milk, the enzyme produces lysophospholipids from the phospholipids. He further explains that the enzyme preparation converts phospholipids to lysophospholipids in each of the above areas. Lysophosphatidylcholine is a lysophospholipid. This is significant and shows that there are unnaturally high amounts of lysophosphatidylcholine in enzyme-modified foods.〔(【引用サイトリンク】title=Biochemistry of Foods )〕 Foods and Products with Unnaturally High Quantities of Lysophosphatidylcholine Modified coconut oil has high levels of lysophosphatidylcholine; look at Mr. Rahman’s page 12 chart 〔http://fos.ubd.edu.bn/sites/default/files/2000-Paper2.pdf〕 to see that naturally phosphatidylcholine is 34 percent of lipids in coconut oil and lysophosphatidylcholine is only four percent. Once modified though, all that phosphatidylcholine could become hydrolyzed and be lysophosphatidylcholine – a demylenating toxin. In 2012, there was a lot said about modified coconut oil’s benefits for tooth brushing. Here is another use for lysophosphatidylcholine – an immune activator. Vaccines.〔(【引用サイトリンク】title=Patent US20110135684 - Use of L-alpha-lysophosphatidylcholine to obtain the differentiation of ... - Google Patents )〕 Diseases Related to Excessive Intake of Unnatural Quantities of Lysophosphatidylcholine What effects would occur from lysophosphatidylcholine in or near the eye? Hypothetically, one suffering from macular degeneration may drop lysophosphatidylcholine, a demyelinating agent, in one's eyes. This would make the retinal vein occlude due to the vasoconstricting effects of lysophosphatidylcholine and could cause wet macular degeneration; conversely, if one is not taking a demyelinating agent into or around one's eye, then one would have dry macular degeneration and no retinal occlusion. More research needs to be done to look into this hypothesis and as Ebrahimi and Handa said about lipid biology, “While lipoproteins in Bruch’s membrane both accumulate and can become oxidized, experimental proof of establishing how lipoprotein accumulation in Bruch’s membrane leads to RPE cell death or drusen formation is currently lacking and would establish a definitive role for lipids in AMD. In the future, it will be necessary for the epidemiologists, genetics, and molecular and cellular biologists to work together to definitively determine how lipid biology influences the development of AMD. It is hoped that greater understanding of the molecular biology of AMD lesions will provide a knowledge based on which to develop multiple treatment targets for the benefit of patients with AMD.” 〔http://www.hindawi.com/journals/jl/2011/802059/〕 Further study needs to be done to determine if the vasoconstriction could be reduced and the vein brought back to normal functioning by eliminating any demyelinating agents in foods, drops, or products. In the Journal of Viral Hepatitis, Nie and Han et al. researched 99 metabolites in Acute-on-chronic liver failure and found, “Our study demonstrated the following 17 metabolites, including LysoPC(18:0), LysoPC(17:0), LysoPC(16:0), LysoPC(15:0), LysoPC(14:0), L-Threonine, Acetoacetic acid, DHAP(18:0), Phenylalanyl Phenylalanine, Bilirubin glucuronide, PA(20:4(5Z,8Z,11Z,14Z)e/2:0),m/z = 210.05, m/z = 475.172, m/z = 797.3, m/z = 599.29, m/z = 258.818 and m/z = 775.318. These 17 metabolites could be used as important potential markers for predicting the prognosis of patients with HBV-related ACLF. 11 metabolites, including LysoPC(14:0), Phenylalanyl Phenylalanine, Bilirubin glucuronide, LysoPC(22:5), m/z = 797.3, m/z = 759.286, m/z = 475.172, m/z = 599.29, m/z = 515.313, m/z = 775.318 and m/z = 809.287 showed disease-monitoring value.” This breakthrough research shows that in the acute-on-chronic liver failure the lysophosphatidylcholine and the mechanisms that directly surround it play a huge part in downfall. The other 82 metabolites studied in this paper do not have negative numbers. The LPCs are the ones implicated in liver cirrhosis and hepatitis. Along the same lines, Neiderhiser and Maksem proved that ethanol (drinking alcohol) increases lysophosphatidylcholine absorption in the stomach.〔(【引用サイトリンク】title=Gastric mucosal damage induced by combination of ethanol and lysophosphatidylcholine )〕 Perhaps, ingesting unnaturally large amounts of lysoPC in addition to large amounts of alcohol is the cause of alcoholic liver disease. Lysophosphatidylcholine - The Reason Why Smoking is Bad for those with Multiple Sclerosis It is well known that smoking tobacco makes multiple sclerosis worse 〔(【引用サイトリンク】title=Smoking and Multiple Sclerosis - Smoking Mechanisms of Action in Multiple Sclerosis )〕 although none can explain why, until now. Pasini and group at the University of Verona found that smoking induces phospholipase and increases lysoPC levels,〔(【引用サイトリンク】title=Lysophosphatidylcholine and Carotid Intima-Media Thickness in Young Smokers: A Role for Oxidized LDL-Induced Expression of PBMC Lipoprotein-Associated Phospholipase A2? )〕 which makes lesions in high numbers. Pasini et al. said, “…smokers compared to non-smokers, had significantly higher levels of circulating oxLDL (44.7±9.1 versus 15.8±7.5 µg/ml respectively, P<0.001). Moreover our results showed higher plasma levels of Lp-PLA2 (256.7±63.1 versus 191.3±48.0 ng/ml respectively, P<0.001) and of lysoPC (133.8±39.4 µmol/l and 95.3±20.8 µmol/l respectively, P<0.001) in smokers compared to non-smokers. These data are presented in Table 1. We also found a significant positive correlation between plasma concentrations of ox-LDL and of LpPLA2 (r=0.654, P<0.001) and between plasma concentrations of Lp-PLA2 and of lysoPC in the whole population of subjects studied (r=0.639, P<0.001),” They went on to say, ”Moreover the correlation between lysoPC and CIMT together with the finding that lysoPC up-regulates proteoglycan synthesis suggests that lysoPC may be a link between smoking and intimal thickening.” Hypothetically, the reason not every smoker has MS may be due to a cumulative effect of lysoPC, which would depend on what foods and products everyone’s using. ==See also== * 1-Lysophosphatidylcholine 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Lysophosphatidylcholine」の詳細全文を読む スポンサード リンク
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