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Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 is an enzyme that in humans is encoded by the ''MAP3K7IP2'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23118 )〕 The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKL through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts.〔 Mutations in MAP3K7IP2 have been associated with human congenital heart defects. == Interactions == MAP3K7IP2 has been shown to interact with: * HDAC3,〔 * MAP3K7IP1,〔 * MAP3K7IP3,〔 * MAP3K7,〔〔〔 * NFKB1, * NUMBL, * Nuclear receptor co-repressor 1,〔 * TRAF2,〔 and * TRAF6.〔〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「MAP3K7IP2」の詳細全文を読む スポンサード リンク
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