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Membrane-bound transcription factor site-2 protease
Membrane-bound transcription factor site-2 protease, or site-2 protease (S2P) for short, is an enzyme () encoded by the gene which liberates the N-terminal fragment of sterol regulatory element-binding protein (SREBP) transcription factors from membranes. S2P cleaves the transmembrane domain of SREPB, making it a member of the class of intramembrane proteases. S2P endopeptidase () is an enzyme. This enzyme catalyses the following chemical reaction : Cleaves several transcription factors that are type-2 transmembrane proteins within membrane-spanning domains. Known substrates include sterol regulatory element-binding protein (SREBP)-1, SREBP-2 and forms of the transcriptional activator ATF6. This enzyme belongs to the peptidase family M50. ==See also==
* Membrane-bound transcription factor site-1 protease
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