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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク MCM6 ： ウィキペディア英語版 MCM6 DNA replication licensing factor MCM6 is a protein that in humans is encoded by the ''MCM6'' gene. MCM6 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. == Function == The MCM complex consisting of MCM6 (this protein) and MCM2, 4 and 7 possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4175 )〕 Mcm 6 has recently been shown to interact strongly Cdt1 at defined residues, by mutating these target residues Wei ''et al''. observed lack of Cdt1 recruitment of Mcm2-7 to the pre-RC. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「MCM6」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.