翻訳と辞書 Words near each other ・ McNulty, Oregon ・ McNutt ・ McNutt Rural Historic District ・ McNutt School ・ McNutt, Mississippi ・ McNutts Island, Nova Scotia ・ MCO ・ MCOLN1 ・ MCOLN2 ・ MCOLN3 ・ MComix ・ MCON GROUP ・ McOndo ・ McOndo (book) ・ MCOP ・ MCOPPB ・ Mcor Technologies Ltd ・ MCOT ・ McOwen ・ MCP ・ MCP Altona ・ MCP-1600 ・ MCP1 ・ MCPA ・ McParland ・ McPartland ・ McPartland Mountain ・ McPartlin ・ McPaul, Iowa ・ MCPB Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク MCOPPB ： ウィキペディア英語版 MCOPPB MCOPPB is a drug which acts as a potent and selective agonist for the nociceptin receptor, with a pKi of 10.07 and much weaker activity at other opioid receptors. It has only moderate affinity for the mu opioid receptor, weak affinity for the kappa opioid receptor and negligible binding at the delta opioid receptor. In animal studies, MCOPPB produces potent anxiolytic effects, with no inhibition of memory or motor function, and only slight sedative side effects which do not appear until much higher doses than the effective anxiolytic dose range.〔Hirao A, Imai A, Sugie Y, Yamada Y, Hayashi S, Toide K. Pharmacological characterization of the newly synthesized nociceptin/orphanin FQ-receptor agonist 1-()-2-()-1H-benzimidazole as an anxiolytic agent. ''Journal of Pharmacological Sciences''. 2008 Mar;106(3):361-8. PMID 18319566〕〔Hayashi S, Hirao A, Imai A, Nakamura H, Murata Y, Ohashi K, Nakata E. Novel non-peptide nociceptin/orphanin FQ receptor agonist, 1-()-2-()-1H-benzimidazole: design, synthesis, and structure-activity relationship of oral receptor occupancy in the brain for orally potent antianxiety drug. ''Journal of Medicinal Chemistry''. 2009 Feb 12;52(3):610-25. PMID 19125610〕 == References == 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「MCOPPB」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.