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| Section2 = }} MG132 is a specific, potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). It reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. MG132 activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. MG132 also inhibits NF-κB activation with an IC50 of 3 µM and prevents β-secretase cleavage. ==References== * (【引用サイトリンク】 publisher = merck-chemicals.com ) * (【引用サイトリンク】 MG-132 ) 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「MG132」の詳細全文を読む スポンサード リンク
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