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MIXL1 Mixl1 is a paired-type homeobox transcription factor weighing 27 kDa with 232 amino acids.〔# "Homeobox Protein MIXL1 - MIXL1 - ''Homo sapiens'' (Human)." Homeobox Protein MIXL1 - MIXL1 - ''Homo sapiens'' (Human). N.p., 16 Apr. 2014. Web. 15 Apr. 2014.()〕 Mixl1 transcription factor preferentially binds to the DNA sequence TAAT on the Mix gene. Mixl1 is part of the Mix/Bix family of transcription factors, with Mixl1 being the only member identified in humans. The Xenopus Mix gene and human Mix genese are homologues. Mixl1 is functionally similar to the Xenopus Mix.1.〔# Cloning, expression analysis, and chromosomal localization of murine and human homologues of a Xenopus Mix gene. Robb, L., Hartley, L., Begley, C. G., Brodnicki, T. C., Copeland, N. G., Gilbert, D. J., Jenkins, N. A. and Elefanty, A. G. Dec. Dyn. 219, 497-504 (2000)(PMID 11084649 ).〕 Mixl1 is transiently expressed in the primitive streak of the gastrulating embryo, between embryonic day (E) 12 through E.19. Its expression is restricted to embryonic mesoderm precursors.〔# Mixl1 is required for axial mesendoderm morphogenesis and patterning in the murine embryo. Hart, A.H., Hartley, L., Sourris, K., Stadler, E.S., Li, R., Stanley, E.G., Tam, P.P., Elefanty, A.G., Robb, L. Development (2002) (PMID 12117810 )〕 Also known as: Mix; Mix1; Mild1 == Function ==
Mixl1 plays a role in mesoderm patterning and tissue specification at gastrulation. It marks cells destined to be mesoderm and endoderm. Mixl1 expression is required for both mesoderm development and hematopoiesis. Mixl1 homologues are also a necessary intermediate for BMP4-induced ventral mesoderm patterning and differentiating ES cells.〔# The primitive streak gene Mixl1 is required for efficient haematopoiesis and BMP4-induced ventral mesoderm patterning in differentiating ES cells. Ng, E.S., Azzola, L., Sourris, K., Robb, L., Stanley, E.G., Elefanty, A.G. Development (2005) (PMID 15673572 )〕
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