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MKP5
MKP5 is a member of DS-MKP family. Its structural features include the presence of an N-terminus (NT) domain of unknown function in addition to the MKB and DSP domains that are characteristic of other members of DS-MKP family. MKP5 shows preference for dephosphorylating JNK and p38 MAPKs but not ERK. It has been hypothesized that the novel NT domain is possibly a protein interaction domain that may be involved in interaction with other cellular proteins and thereby providing a mechanism for cross-talk between MAPK and other signaling pathways involved in regulating cellular functions. The NT domain thus suggests another element of complexity in the biological function of DS-MKPs. ==References==
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「MKP5」の詳細全文を読む
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