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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク ML-154 ： ウィキペディア英語版 ML-154 ML-154 (NCGC-84) is a drug which acts as a selective, non-peptide antagonist at the neuropeptide S receptor NPSR.〔Patnaik S, Marugan JJ, Liu K, Zheng W, Southall N, Dehdashti SJ, Thorsell A, Heilig M, Bell L, Zook M, Eskay B, Brimacombe KR, Austin CP. Structure-activity relationship of imidazopyridinium analogues as antagonists of neuropeptide S receptor. ''J Med Chem''. 2013 Nov 27;56(22):9045-56. doi: 10.1021/jm400904m PMID 24171469〕 In animal studies it decreases self-administration of alcohol in addicted rats, and lowers motivation for alcohol rewards, suggesting a potential application for NPS antagonists in the treatment of alcoholism.〔Thorsell A, Tapocik JD, Liu K, Zook M, Bell L, Flanigan M, Patnaik S, Marugan J, Damadzic R, Dehdashti SJ, Schwandt ML, Southall N, Austin CP, Eskay R, Ciccocioppo R, Zheng W, Heilig M. A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats. ''J Neurosci''. 2013 Jun 12;33(24):10132-42. doi: 10.1523/JNEUROSCI.4742-12.2013 PMID 23761908〕 == See also == * Neuropeptide S receptor 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「ML-154」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.