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MTHFD2L
NAD-dependent methylenetetrahydrofolate dehydrogenase 2-like protein (MTHFD2L), also known as bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, is an enzyme that in humans is encoded by the ''MTHFD2L'' gene on chromosome 4.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/gene/441024 )〕〔(【引用サイトリンク】 url = http://www.uniprot.org/uniprot/Q9H903 )〕 This enzyme localizes to the inner mitochondrial membrane, where it performs the NADP+-dependent dehydrogenase/cyclohydrolase activity as part of the mitochondrial pathway to convert folate to formate.
It is associated with fluctuations in cytokine secretion in response to viral infections and vaccines.〔
== Structure ==
The ''MTHFD2L'' gene consists of nine exons and is conserved among mammals. This gene encodes a 340-residue protein that is homologous to the mitochondrial bifunctional dehydrogenase/cyclohydrolase (MTHFD2) and to the N-terminal dehydrogenase/cyclohydrolase domains of cytoplasmic and mitochondrial C1-THF synthases (MTHFD1 and MTHFD1L, respectively). The MTHFD2L protein contains a predicted N-terminal mitochondrial targeting sequence and four amino acids (Lys-93, Arg-206, Gly-211, and Arg-238) necessary for the protein's dehydrogenase/cyclohydrolase activity. Three classes of MTHFD2L RNA transcripts have been detected at equal levels in adult human brain and placenta, though their translation into stable proteins in vivo has not been confirmed.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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