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・ Mykyta Kravchenko
・ Mykyta Kryukov
・ Mykyta Nesterenko
・ Mykyta Polyulyakh
・ Mykyta Senyk
・ Mykyta Shevchenko
・ Mykyta Tatarkov
・ Mykyta the Fox
・ Mykytivskyi District
・ Mykyty
・ MYL
・ MYL1
・ MYL12B
・ MYL2
・ MYL3
MYL4
・ MYL6
・ MYL6B
・ MYL7
・ MYL9
・ MYLA
・ Myla Dalbesio
・ Myla Goldberg
・ Mylabris
・ Mylabris flavoguttata
・ Mylabris oleae
・ Mylabris phalerata
・ Mylabris pustulata
・ Mylabris sennae
・ Mylacanthus


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MYL4 : ウィキペディア英語版
MYL4

Atrial Light Chain-1 (ALC-1), also known as Essential Light Chain, Atrial is a protein that in humans is encoded by the ''MYL4'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4635 )〕 ALC-1 is expressed in fetal cardiac ventricular and fetal skeletal muscle, as well as fetal and adult cardiac atrial tissue. ALC-1 expression is reactivated in human ventricular myocardium in various cardiac muscle diseases, including hypertrophic cardiomyopathy, dilated cardiomyopathy, ischemic cardiomyopathy and congenital heart diseases.
==Structure==
ALC-1 is a 21.6 kDa protein composed of 197 amino acids.〔(【引用サイトリンク】url=http://www.heartproteome.org/copa/ProteinInfo.aspx?QType=Protein%20ID&QValue=P12829 )〕 ALC-1 is expressed in fetal cardiac ventricular and fetal skeletal muscle, as well as fetal and adult cardiac atrial tissue.〔 ALC-1 binds the neck region of muscle myosin in adult atria. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. Relative to ventricular essential light chain VLC-1, ALC-1 has an additional ~40 amino-acid N-terminal region that contains four to eleven residues that are critical for binding actin and modulating myosin kinetics.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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