Mahāyoga-yana is associated with the masculine principle and is for those whose primary defilement is aggression. In Mahāyoga, one visualizes oneself as the divinity with consort. "All manifestation, thoughts and appearances are considered to be the sacred aspects of the divinities within relative truth," in the words of Tulku Thondup. By visualizing all phenomena as the deities of the mandala of buddhahood, in the development stage, all appearances are purified.〔Ray, Reginald A. (2002). ''Indestructibe Truth: The Living Spirituality of Tibetan Buddhism - The World of Tibetan Buddhism Volume One''. Boston, Massachusetts, U.S.A.: Shambala Publications, Inc. ISBN 1-57062-910-2. P.124.〕

One particular keynote of mahāyoga-yana has to do with the use of visualization. In the Vajrayana in general, one visualizes oneself as the buddha, thus giving external form to the enlightenment within. Like-wise, one visualizes the external world as pure and sacred, thus under-cutting the usual practice of taking things as impure and defiled. In mahāyoga, one comes to the realization that actually all of our everyday experience is a visualization. Just as we can visualize ourselves as a buddha and the world as pure, so we can visualize ourselves as an existent ego and the world as defiled. Realizing that all of our images and conceptions of reality are in fact complex visualizations, we gain a unique entry into the underpinnings of the conventional world and gain a certain kind of unparalleled leverage over it. This is reflected in the mahāyoga-yana teaching of the "eight cosmic commands," eight kinds of ways to intervene in the operation of the conventional world and alter its momentum for the benefit of others.〔