翻訳と辞書 Words near each other ・ Maravil Thirivu Sookshikkuka ・ Maravilha ・ Maravilha, Santa Catarina ・ Maravilhas ・ Maravilla ・ Maravilla (Los Angeles Metro station) ・ Maravilla Americana ・ Maravilla Island ・ Maravilla Tenejapa ・ Maravillas ・ Maravillas Creek ・ Maravillas de Colombia S.A. ・ Maravillas de Jesús ・ Maravillas Formation ・ Maravillas Rojo ・ Maraviroc ・ Maravići ・ Maravovo ・ Marawa, Libya ・ Marawaan Bantam ・ Marawah ・ Marawah Island ・ Marawan language ・ Marawanagoda ・ Marawara ・ Marawara District ・ Marawi ・ Marawiel ・ Marawila ・ Marawing 1-L Malamut Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Maraviroc ： ウィキペディア英語版 Maraviroc Maraviroc (brand-named Selzentry, or Celsentri outside the U.S.) is an antiretroviral drug in the CCR5 receptor antagonist class used in the treatment of HIV infection. It is also classed as an entry inhibitor. It also appeared to reduce graft-versus-host disease in patients treated with allogeneic bone marrow transplantation for leukemia, in a phase 1/2 study.〔http://www.uphs.upenn.edu/news/News_Releases/2012/07/hiv/〕〔Blocade of lymphocyte chemotaxis in visceral graft-versus-host disease, Ran Reshef et al., New England Journal of Medicine, 367:135 (July 12, 2012)〕 ==Mechanism of action== Maraviroc is an entry inhibitor. Specifically, maraviroc is a negative allosteric modulator of the CCR5 receptor, which is found on the surface of certain human cells. The chemokine receptor CCR5 is an essential co-receptor for most HIV strains and necessary for the entry process of the virus into the host cell. The drug binds to CCR5, thereby blocking the HIV protein gp120 from associating with the receptor. HIV is then unable to enter human macrophages and T-cells. Because HIV can also use other coreceptors, such as CXCR4, an HIV tropism test such as a trofile assay must be performed to determine if the drug will be effective. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Maraviroc」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.