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Melanophilin : ウィキペディア英語版 | Melanophilin
Melanophilin is a carrier protein which in humans is encoded by the ''MLPH'' gene. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. == Function ==
This gene encodes a member of the exophilin subfamily of Rab effector proteins. The protein forms a ternary complex with the small Ras-related GTPase Rab27A in its GTP-bound form and the motor protein myosin Va. A similar protein complex in mouse functions to tether pigment-producing organelles called melanosomes to the actin cytoskeleton in melanocytes, and is required for visible pigmentation in the hair and skin.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79083 )〕 In melanocytic cells MLPH gene expression may be regulated by MITF.
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