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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Mertansine ： ウィキペディア英語版 Mertansine |Section2= |Section3= }} Mertansine refers to the thiol-containing maytansinoid DM1, which for therapeutic purposes is attached to a monoclonal antibody through reaction of the thiol group with a linker structure to create an antibody-drug conjugate (ADC). Experimental ADCs with this design include lorvotuzumab mertansine. ==Mechanism of action== Mertansine is a tubulin inhibitor, meaning that it inhibits the assembly of microtubules by binding to tubulin (at the rhizoxin binding site).〔National Cancer Institute: (Definition of Maytansine )〕 The monoclonal antibody binds specifically to a structure (usually a protein) occurring in a tumour, thus directing mertansine into this tumour. This concept is called targeted therapy. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Mertansine」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.