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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Metadoxine ： ウィキペディア英語版 Metadoxine Metadoxine, also known as pyridoxine-pyrrolidone carboxylate, is a drug used to treat chronic and acute alcohol intoxication.〔 Metadoxine improved the clinical signs of acute alcohol intoxication and accelerated alcohol clearance from the blood 〔 Metadoxine extended release is being evaluated as a treatment in human clinical trials for individuals with attention deficit hyperactivity disorder (ADHD) and for individuals with fragile X syndrome.〔 Metadoxine is an ion pair salt of pyridoxine and L-pyroglutamate (L-PGA). Pyridoxine (vitamin B6) is a precursor of coenzymes including pyridoxal 5’-phosphate (PLP), which accelerates the metabolic degradation of ethanol and prevents adenosine triphosphate (ATP) inactivation by acetaldehyde. Pyridoxal phosphate dependent enzymes also play a role in the biosynthesis of four important neurotransmitters: serotonin (5-HT), epinephrine, norepinephrine and GABA: see vitamin B6 functions. L-PGA is present in the diet and is produced endogenously by enzymatic conversion of gamma-glutamyl amino acids to L-PGA and free amino acids. In the central nervous system (CNS), L-PGA was found to have a role in composition of neuro-active molecules. Its production has been linked to hepatic gamma-glutamyl transferase activity and levels of reduced glutathione (GSH). Lastly, it was shown that L-PGA facilitates ATP synthesis by stimulating de novo synthesis of purines. ==History== Metadoxine is predominantly used as metadoxine immediate release formulation in developing nations for acute alcohol intoxication and chronic alcoholic liver disease. Alternate names include: * Abrixone (Eurodrug, Mexico) * Alcotel (Il Yang, South Korea) * Ganxin (Qidu Pharmaceutical, China) * Metadoxil (Baldacci, Georgia; Baldacci, Italy; Baldacci, Lithuania; CSC, Russian Federation; Eurodrug, Colombia; Eurodrug, Hungary; Eurodrug, Thailand) * Micro (HC, India) * Viboliv (Dr. Reddy's, India) * Alcoliv (India) * Xin Li De (Zhenyuan Pharm, China)〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Metadoxine」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.