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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Methohexital ： ウィキペディア英語版 Methohexital Methohexital or methohexitone (marketed under the brand name Brevital) is a drug which is a barbiturate derivative. It is classified as short-acting, and has a rapid onset of action. It is similar in its effects to sodium thiopental, a drug with which it competed in the market for anaesthetics. ==Pharmacology== Methohexital binds to a distinct site which is associated with Cl− ionophores at GABAA receptors.〔Katzung, Bertram G., Basic and Clinical Pharmacology, 10th ed., p. 406-407〕 This increases the length of time which the Cl− ionopores are open, thus causing an inhibitory effect. Metabolism of methohexital is primarily hepatic (i.e., taking place in the liver) via demethylation and oxidation. Side-chain oxidation is the primary means of metabolism involved in the termination of the drug's biological activity. Protein binding is approximately 73% for methohexital. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Methohexital」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.