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| Section2 = | Section7 = }} Methylchloroisothiazolinone (5-chloro-2-methyl-4-isothiazolin-3-one), also referred to as MCI, is a preservative with antibacterial and antifungal effects within the group of isothiazolinones. It is effective against gram-positive and gram-negative bacteria, yeast, and fungi. Methylchloroisothiazolinone is found in many water-based personal care products and cosmetics. Methylchloroisothiazolinone was first used in cosmetics in the 1970s. It is also used in glue production, detergents, paints, fuels, and other industrial processes. Methylchloroisothiazolinone is known by the registered tradename Kathon CG when used in combination with methylisothiazolinone. Methylchloroisothiazolinone may be used in combination with other preservatives including ethylparaben, benzalkonium chloride, or 2-bromo-2-nitropropane-1,3-diol. ==Safety== In pure form or in high concentrations, methylchloroisothiazolinone is a skin and membrane irritant and causes chemical burns. In the United States, accepted concentrations are 15 ppm in rinse-offs and 8 ppm in other cosmetics. In Canada, the accepted concentrations are 15 ppm and 7.5 ppm respectively.〔(【引用サイトリンク】title=Cosmetic Ingredient Hotlist: Prohibited and Restricted Ingredients )〕 The Canadian levels are also reflected in a paper published in the International Journal of Toxicology. The International Agency for Research on Cancer (IARC), does not currently list methylchloroisothiazolinone as a known, probable, or possible human carcinogen,〔(【引用サイトリンク】title=International Agency for Research on Cancer )〕 nor have ''in vivo'' tests found evidence of carcinogenic activity. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Methylchloroisothiazolinone」の詳細全文を読む スポンサード リンク
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