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Metoprolol, marketed under the tradename Lopressor among others, is a selective β1 receptor blocker medication.〔 It is used to treat high blood pressure, chest pain due to poor blood flow to the heart, and a number of conditions involving an abnormally fast heart rate. It is also used to prevent further heart problems after myocardial infarction and to prevent headaches in those with migraines.〔 It comes in formulations that can be taken by mouth or given intravenously. The medication is often taken twice a day. There is an extended release formulation that is once per day. Metoprolol may be combined with hydrochlorothiazide in a single tablet.〔 Common side effects include trouble sleeping, feeling tired, feeling faint, and abdominal discomfort.〔 Large doses may cause serious toxicity. Risk in pregnancy has not been ruled out.〔(【引用サイトリンク】url=http://www.drugs.com/monograph/metoprolol-succinate.html )〕 It appears to be safe in breastfeeding. Greater care is required with use in those with liver problems or asthma.〔 If stopped this should be done slowly to decrease the risk of further health problems.〔 Metoprolol was first made in 1969. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system. It is available as a generic drug.〔 In 2013, metoprolol was the 19th most prescribed medication in the United States.〔 〕 == Medical uses == Metoprolol is used for a number of conditions, including hypertension, angina, acute myocardial infarction, supraventricular tachycardia, ventricular tachycardia, congestive heart failure, and prevention of migraine headaches.〔(【引用サイトリンク】 url = http://www.drugs.com/monograph/metoprolol-succinate.html )〕 * Treatment of heart failure * Vasovagal syncope * Adjunct in treatment of hyperthyroidism * Long QT syndrome, especially for patients with asthma, as metoprolol's β1 selectivity tends to interfere less with asthma drugs, which are often β2-adrenergic receptor-agonist drugs *Prevention of relapse into atrial fibrillation (controlled-release/extended-release form) Due to its selectivity in blocking the beta1 receptors in the heart, metoprolol is also prescribed for off-label use in performance anxiety, social anxiety disorder, and other anxiety disorders. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Metoprolol」の詳細全文を読む スポンサード リンク
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