翻訳と辞書 Words near each other ・ Mir-124 microRNA precursor family ・ Mir-126 ・ Mir-127 ・ Mir-129 microRNA precursor family ・ Mir-130 microRNA precursor family ・ MiR-132 ・ Mir-133 microRNA precursor family ・ MiR-134 ・ Mir-135 microRNA precursor family ・ Mir-137 ・ MiR-138 ・ Mir-14 microRNA precursor family ・ Mir-143 ・ MiR-144 ・ Mir-145 ・ MiR-146 ・ Mir-148/mir-152 microRNA precursor family ・ Mir-15 microRNA precursor family ・ MiR-150 ・ Mir-153 microRNA precursor family ・ Mir-154 microRNA precursor family ・ MiR-155 ・ Mir-156 microRNA precursor ・ Mir-16 microRNA precursor family ・ Mir-160 microRNA precursor family ・ Mir-166 microRNA precursor ・ Mir-17 microRNA precursor family ・ Mir-172 microRNA precursor family ・ Mir-181 microRNA precursor ・ Mir-184 Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク MiR-146 ： ウィキペディア英語版 MiR-146 __NOTOC__ miR-146 is a family of microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer. This sequence then associates with RISC which effects RNA interference. miR-146 is primarily involved in the regulation of inflammation and other process that function in the innate immune system. Loss of functional miR-146 (and mir-145) could predispose an individual to suffer from chromosome 5q deletion syndrome. miR-146 has also been reported to be highly upregulated in osteoarthritis cartilage, and could be involved in its pathogenesis. == Function == miR-146 is thought to be a mediator of inflammation along with another microRNA, mir-155. The expression of miR-146 is upregulated by inflammatory factors such as interleukin 1 and tumor necrosis factor-alpha. miR-146 dysregulates a number of targets which are mostly involved in toll-like receptor pathways that bring about a cytokine response as part of the innate immune system.〔〔 miR-146 operates in a feedback system or "negative regulatory loop" to finely tune inflammatory responses.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「MiR-146」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.