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MiR-208 __NOTOC__ miR-208 is a family of microRNA precursors found in animals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer. This sequence then associates with RISC which effects RNA interference. In humans, the gene for miR-208 is located in an intron of MYH7. ==Function== miR-208 has been deemed a "myomiR"〔 as it is specifically expressed, or found at much higher levels, in cardiac tissue. Other myomiRs include miR-1 and miR-133.〔 miR-208 is though to be dysregulated in various cardiovascular diseases. miR-208 functions in cardiomyocytes regulating the production of the myosin heavy chain during development.〔 It also responds to stress and forms part of a hormonal signalling cascade in cardiac cells.
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「MiR-208」の詳細全文を読む
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