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MiR-338 __NOTOC__ miR-338 is a family of brain-specific microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer. This sequence then associates with RISC which effects RNA interference. miR-338 is located in an intronic region within the gene for apoptosis-associated tyrosine kinase (AATK). It has been predicted that it may downregulate genes which have a downstream negative effect on AATK expression. == Function ==
miR-338 is a brain-specific miRNA which regulates the expression of cytochrome c oxidase IV (COX4).〔 The mature miR-338 miRNA sequence is complementary to a short section of the 3' untranslated region of COX4 mRNA. This mRNA sequence is presented atop a stem-loop structure, indicating it is accessible to miRNA processing.〔
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