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Michellamine : ウィキペディア英語版 | Michellamine
Michellamine is an atropisomeric alkaloid which has been found to be a strong anti-HIV viral replication inhibitor. It was discovered in the leaves of the ''Ancistrocladus korupensis'' which is a member of the ''Triphyophyllum peltatum'' found in Cameroon. There are 3 michellamines represented as A, B, and C, however, Michellamine B is the most active against the NID-DZ strain of ''HIV-2''. ==Occurrence== Michellamine A and B alkaloids occur naturally in Ancistrocladus korupensis leaves, a ''Triphyophyllum peltatum'' found in Cameroon. Bioactive chemical substances including alkaloids, tannins, and saponin are found in several plants in their roots, leaves, stems, flowers, or bark. Therapeutic chemicals have been found in various plants to treat diseases such as malaria, diabetes, and cancers. The patent for this compound is held by Dr. Kirk Manfredi and others. http://www.google.com/patents/US5455251
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