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Mir-205
In molecular biology miR-205 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. They are involved in numerous cellular processes, including development, proliferation, and apoptosis. Currently, it is believed that miRNAs elicit their effect by silencing the expression of target genes.
The miR-200 family (miR-200a, miR-200b, miR-200c, miR-141 and miR-429) and miR-205 are frequently silenced in advanced cancer. Studies has shown that -- by targeting the transcriptional repressors of E-cadherin, ZEB1 and ZEB2-- Mir-205 is involved in epithelial to mesenchymal transition (EMT) and tumor invasion .
Recently, miR-200 silencing was also reported in cancer stem cells, implying that miR-200 deregulation is a key event in multiple levels of tumor biology. The cause of miR-200 silencing in naturally-occurring cancer cells, however, remains largely unknown.
== Genomic locations ==
Members of miR-200 family including miR -205 are found clustered at two locations in the human genome : 1142000 - 1144500 in chromosome 1 and 6942000 - 6944500 in chromosome 12. Short genomic distance between members suggests that they may function collaboratively and are highly related in sequence.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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