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|Section2= |Section6= |Section7= }} Motretinide is an anti-acne preparation and aromatic analog of retinoic acid. ==Synthesis== The keratolytic analogue motretinide is effective in treating acne and the excess epithelilial growth characeteristic of psoriasis, demonstrating that an aromatic terminal ring is compatible with activity. The synthesis〔W. Bollag, R. Rueegg, and G. Ryser, (1980); Chem. Abstr., 93, 71312J (1980).〕 passes through the related orally active antipsoriatic/antitumor agent etretinate (3). These synthetic compounds have a wider safety margin than the natural materials. Etretinate is synthesized〔 EW. Bollag, R. Rueegg, and G. Ryser, (1980); Chem. Abstr., 93_, 71314m (1980).〕 from 2,3,5-trimethylanisole by sequential Blanc chloromethylation (HCl and formaldehyde) followed by conversion to the ylide with triphenylphosphine and BuLi (2). Wittig olefination then leads to Etretinate (3). Etretinate may then be saponified, activated by PCl3 to the acid chloride, and then reacted with ethylamine to give motretinide (4). 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Motretinide」の詳細全文を読む スポンサード リンク
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