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Mucunain
The proteolytic enzyme mucunain is a protein in the tissues of certain legumes of the genus ''Mucuna'', especially velvet bean (''Mucuna pruriens'').〔NCBI Protein database (mucunain (Mucuna pruriens) GenBank: ACB87490.1 )〕〔Reddy,V.B. et al. (Cowhage-evoked itch is mediated by a novel cysteine protease: a ligand of protease-activated receptors ) J. Neurosci. 28 (17), 4331-4335 (2008) PMID 18434511〕 In these species the mucunain is found in stiff hairs, or trichomes, covering the seed pods. When the hairs rub off and come in contact with skin they cause severe itching and irritation.〔〔Shelley WB, Arthur RP. (Mucunain, the active pruritogenic proteinase of cowhage ). ''Science''. 1955;122:469–470. PMID 13255877〕 ==References==
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