翻訳と辞書 Words near each other ・ Myocardiodystrophy ・ Myocarditis ・ MyOcean ・ Myochama tasmanica ・ Myochamidae ・ Myocheong ・ Myochromella ・ Myoclonic astatic epilepsy ・ Myoclonic dystonia ・ Myoclonic epilepsy ・ Myoclonic triangle ・ Myoclonus ・ Myocyte ・ Myocyte-specific enhancer factor 2A ・ Myocytolysis ・ MyoD ・ Myodini ・ Myodisc ・ Myodocarpaceae ・ Myodocarpus ・ Myodocarpus angustialatus ・ Myodocopa ・ Myodocopida ・ Myoepithelial cell ・ Myoepithelioma of the head and neck ・ Myofascial pain syndrome ・ Myofascial release ・ Myofascial trigger point ・ Myofibril ・ Myofibroblast Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク MyoD ： ウィキペディア英語版 MyoD MyoD is a protein that plays a major role in regulating muscle differentiation. MyoD, which was discovered in the laboratory of Harold M. Weintraub, belongs to a family of proteins known as myogenic regulatory factors (MRFs).〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4654 )〕 These bHLH (basic helix loop helix) transcription factors act sequentially in myogenic differentiation. MRF family members include MyoD, Myf5, myogenin, and MRF4 (Myf6). MyoD is one of the earliest markers of myogenic commitment. MyoD is expressed at extremely low and essentially undetectable levels in quiescent satellite cells, but expression of MyoD is activated in response to exercise or muscle tissue damage. The effect of MyoD on satellite cells is dose-dependent; high MyoD expression represses cell renewal and induces apoptosis. Although MyoD marks myoblast commitment, muscle development is not dramatically ablated in mouse mutants lacking the MyoD gene. This is likely due to functional redundancy from Myf5. Nevertheless, the combination of MyoD and Myf5 is vital to the success of myogenesis. MyoD is also an important effector for the fast-twitch muscle fiber (type IIa and IIx) phenotype. ==History== MyoD was first described as a nuclear phosphoprotein in 1988 by Tapscott, Davis, Thayer, Cheng, Weintraub, and Lassar in Science. The researchers expressed the complementary DNA (cDNA) of the murine MyoD protein in a different cell lines (fibroblast and adipoblast) and found MyoD converted them to myogenic cells. The following year, the same research team performed several tests to determine both the structure and function of the protein, confirming their initial proposal that the active site of the protein consisted of the helix loop helix (now referred to as basic helix loop helix) for dimerization and a basic site upstream of this bHLH region facilitated DNA binding only once it became a protein dimer. MyoD has since been an active area of research as still relatively little is known concerning many aspects of its function. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「MyoD」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.