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|Section2= }} Myriocin, also known as antibiotic ISP-1 and thermozymocidin, is an atypical amino acid and an antibiotic derived from certain thermophilic fungi. Among the producing strains are ''Mycelia sterilia''〔(Myriocin ) from Fermentek〕 and ''Isaria sinclairii''. Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis. Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. Myriocin was shown to inhibit the proliferation of an IL-2-dependent mouse cytotoxic T cell line. Myriocin possesses immunosuppressant activity. It is reported to be 10- to 100-fold more potent than ciclosporin. The multiple sclerosis drug fingolimod was derived from myriocin by using structure–activity relationship studies to determine the parts of the molecule important to its activity. ==References== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Myriocin」の詳細全文を読む スポンサード リンク
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