翻訳と辞書 Words near each other ・ N,N-Diisopropylethylamine ・ N,N-Dimethyl-1-naphthylamine ・ N,N-Dimethyldopamine ・ N,N-Dimethylethylamine ・ N,N-dimethylformamidase ・ N,N-Dimethylsphingosine ・ N,N-Dimethyltryptamine ・ N,N′-Dimethyl-1,3-propanediamine ・ N,O-Dimethyl-4-(2-naphthyl)piperidine-3-carboxylate ・ N,O-Dimethylhydroxylamine ・ N- ・ N-(1-Naphthyl)ethylenediamine ・ N-(2-Hydroxypropyl) methacrylamide ・ N-(long-chain-acyl)ethanolamine deacylase ・ N-(p-amylcinnamoyl)anthranilic acid ・ N-(S)-Fenchyl-1-(2-morpholinoethyl)-7-methoxyindole-3-carboxamide ・ N-105 National Highway ・ N-110 National Highway ・ N-110 road (Spain) ・ N-111 road (Spain) ・ N-113 road (Spain) ・ N-120 National Highway ・ N-120 road (Spain) ・ N-121 road (Spain) ・ N-122 road (Spain) ・ N-123 road (Spain) ・ N-124 road (Spain) ・ N-125 National Highway ・ N-135 road (Spain) ・ N-138 road (Spain) Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク N-(S)-Fenchyl-1-(2-morpholinoethyl)-7-methoxyindole-3-carboxamide ： ウィキペディア英語版 N-(S)-Fenchyl-1-(2-morpholinoethyl)-7-methoxyindole-3-carboxamide 7-methoxy-1-(2-morpholinoethyl)-N-((1S,4R)-1,3,3-trimethylbicyclo()heptan-2-yl)-1H-indole-3-carboxamide (N-()-1-()-7-methoxyindole-3-carboxamide, UR-12, MN-25) is a drug invented by Bristol-Myers Squibb,〔(CANNABINOID RECEPTOR MODULATORS, THEIR PROCESSES OF PREPARATION, AND USE OF CANNABINOID RECEPTOR MODULATORS IN TREATING RESPIRATORY AND NON-RESPIRATORY DISEASES. WO 2001/58869 )〕 that acts as a reasonably selective agonist of peripheral cannabinoid receptors.〔(Rulin Zhao, ''et al.'' Improved procedure for the preparation of 7-methoxy-2-methyl-1-(2-morpholinoethyl)-1H-indole-3-carboxylic acid, key intermediate in the synthesis of novel 3-amidoindole and indolopyridone cannabinoid ligands. ARKIVOC 2010 (vi):89-95. )〕 It has moderate affinity for CB2 receptors with a Ki of 11nM, but 22x lower affinity for the psychoactive CB1 receptors with a Ki of 245nM. The indole 2-methyl derivative has the ratio of affinities reversed however, with a Ki of 8nM at CB1 and 29nM at CB2,〔 〕 which contrasts with the usual trend of 2-methyl derivatives having increased selectivity for CB2 (cf. JWH-018 vs JWH-007, JWH-081 vs JWH-098). Chemically, it is closely related to another indole-3-carboxamide synthetic cannabinoid, Org 28611, but with a different cycloalkyl substitution on the carboxamide, and the cyclohexylmethyl group replaced by morpholinylethyl, as in JWH-200 or A-796,260. Early compounds such as these have subsequently led to the development of a large number of related indole-3-carboxamide cannabinoid ligands.〔 〕 ==See also== * A-834,735 * AB-001 * AM-1221 * JTE 7-31 * JWH-203 * MDA-19 * SR-144,528 * UR-144 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「N-(S)-Fenchyl-1-(2-morpholinoethyl)-7-methoxyindole-3-carboxamide」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.