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・ N-acetylornithine carbamoyltransferase
・ N-acetylphosphatidylethanolamine-hydrolysing phospholipase D
・ N-Acetylprocainamide
・ N-Acetylserotonin
・ N-acetylserotonin O-methyltransferase-like protein
・ N-Acetyltalosaminuronic acid
・ N-acetyltransferase
・ N-acetyltransferase 1
・ N-acetyltransferase 2
・ N-Acyl homoserine lactone
・ N-acyl phosphatidylethanolamine-specific phospholipase D
・ N-acyl-D-amino-acid deacylase
・ N-acyl-D-aspartate deacylase
・ N-acyl-D-glutamate deacylase
・ N-Acylamides
N-Acylethanolamine
・ N-acylethanolamine acid amide hydrolase
・ N-acylglucosamine 2-epimerase
・ N-acylglucosamine-6-phosphate 2-epimerase
・ N-acylhexosamine oxidase
・ N-acylmannosamine 1-dehydrogenase
・ N-acylmannosamine kinase
・ N-acylneuraminate cytidylyltransferase
・ N-acylneuraminate-9-phosphatase
・ N-acylneuraminate-9-phosphate synthase
・ N-Acylphosphatidylethanolamine
・ N-acylsphingosine galactosyltransferase
・ N-alkylglycine oxidase
・ N-alpha-acetyltransferase 10
・ N-Arachidonoyl dopamine


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N-Acylethanolamine : ウィキペディア英語版
N-Acylethanolamine

An ''N''-acylethanolamine is a type of fatty acid amide formed when one of several types of acyl group is linked to the nitrogen atom of ethanolamine. These amides conceptually can be formed from a fatty acid and ethanolamine with the release of a molecule of water, but the known biological synthesis uses a specific phospholipase D to cleave the phospholipid unit from ''N''-acylphosphatidylethanolamines. Another route relies on the transesterification of acyl groups from phosphatidylcholine by an ''N''-acyltransferase (NAT) activity. The suffixes ''-amine'' and ''-amide'' in these names each refer to the single nitrogen atom of ethanolamine that links the compound together: it is termed "amine" in ethanolamine because it is considered as a free terminal nitrogen in that subunit, while it is termed "amide" when it is considered in association with the adjacent carbonyl group of the acyl subunit. Names for these compounds may be encountered with either "amide" or "amine" varying by author.〔For example, note synonyms in PubChem for (oleoylethanolamine ).〕
Examples of ''N''-acylethanolamines include:〔The list and references provided are based on background discussion in 〕
* Anandamide (''N''-arachidonoylethanolamine) is the amide of arachidonic acid (20:4 ω-6) and ethanolamine. It is the ligand of both cannabinoid receptors and vanilloid receptor that attenuates pain sensation.
* ''N''-Palmitoylethanolamine is the amide of palmitic acid (16:0) and ethanolamine. It has anti-inflammatory activity and also attenuates pain sensation.〔
* ''N''-Oleoylethanolamine is the amide of oleic acid (18:1) and ethanolamine. It has anorexic effects and enables fat breakdown by stimulating PPAR-alpha.
* ''N-''Stearoylethanolamine is the amide of stearic acid (18:0) and ethanolamine. It has pro-apoptotic activity. It operates independently of the known cannabinoid and vanilloid receptors targeted by anandamide.〔
* ''N-''Docosahexaenoylethanolamine is the amide of docosahexaenoic acid (22:6) and ethanolamine. It has anti-proliferative effects on prostate cancer cell lines and promotes synaptogenesis. 〔 〕〔 〕



抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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