翻訳と辞書 Words near each other ・ N-acyl phosphatidylethanolamine-specific phospholipase D ・ N-acyl-D-amino-acid deacylase ・ N-acyl-D-aspartate deacylase ・ N-acyl-D-glutamate deacylase ・ N-Acylamides ・ N-Acylethanolamine ・ N-acylethanolamine acid amide hydrolase ・ N-acylglucosamine 2-epimerase ・ N-acylglucosamine-6-phosphate 2-epimerase ・ N-acylhexosamine oxidase ・ N-acylmannosamine 1-dehydrogenase ・ N-acylmannosamine kinase ・ N-acylneuraminate cytidylyltransferase ・ N-acylneuraminate-9-phosphatase ・ N-acylneuraminate-9-phosphate synthase ・ N-Acylphosphatidylethanolamine ・ N-acylsphingosine galactosyltransferase ・ N-alkylglycine oxidase ・ N-alpha-acetyltransferase 10 ・ N-Arachidonoyl dopamine ・ N-Arachidonylglycine ・ N-ary associativity ・ N-ary code ・ N-ary group ・ N-back ・ N-benzoyl-4-hydroxyanthranilate 4-O-methyltransferase ・ N-Benzoyl-N'-phenylurea ・ N-benzyloxycarbonylglycine hydrolase ・ N-body choreography ・ N-body problem Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク N-Acylphosphatidylethanolamine ： ウィキペディア英語版 N-Acylphosphatidylethanolamine ''N''-Acylphosphatidylethanolamines (NAPEs) are hormones released by the small intestine into the bloodstream when it processes fat. NAPEs travel to the hypothalamus in the brain and suppress appetite. This mechanism could be relevant for treating obesity.〔Dunham, Will (Nov 26, 2008). "(Gut chemical may inspire new way to fight obesity )". ''Reuters'' Accessed 27 Nov. 2008〕 ==Endocannabinoid precursor== ''N''-Acylphosphatidylethanolamines are also an important intermediaries in the biosynthesis of endocannabinoids. NAPEs are formed from phosphatidylethanolamines, a group of cell membrane phospholipids characteristic of nervous tissue. After being cleaved by phospholipases, NAPEs can be transformed into ''N''-acylethanolamines, including the endocannabinoid anandamide. While NAPE-PLD is the enzyme responsible for catalyzing said release of N-acylethanolamine (NAE) from N-acyl-phosphatidylethanolamine (NAPE), this specific subtype of phospholipase D is not responsible for the formation of the anandamide. The crystal structure of human N-acyl phosphatidylethanolamine-specific phospholipase D (NAPE-PLD) reveals how this membrane enzyme generates anandamide and other bioactive lipid amides from membrane NAPEs. A hydrophobic cavity in NAPE-PLD provides an entryway for the substrate NAPE into the active site, where a binuclear zinc center orchestrates its hydrolysis. Unexpectedly, the structure unveils bile acids bind the membrane enzyme, enhancing dimer assembly and enabling catalysis. These findings suggest NAPE-PLD might orchestrate a direct crosstalk between bile acids and lipid amide signals.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「N-Acylphosphatidylethanolamine」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.