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Nuclear receptor co-repressor 1
The nuclear receptor co-repressor 1 also known as thyroid-hormone- and retinoic-acid-receptor-associated co-repressor 1 (TRAC-1) is a protein that in humans is encoded by the ''NCOR1'' gene.
NCOR1 is a transcriptional coregulatory protein which contains several nuclear receptor interacting domains. In addition, NCOR1 appears to recruit histone deacetylases to DNA promoter regions. Hence NCOR1 assists nuclear receptors in the down regulation of gene expression.〔
Loss of function of this protein significantly increases the strength and power of mouse muscles.
== Interactions ==
Nuclear receptor co-repressor 1 has been shown to interact with:
* Androgen receptor,
* CHD1,
* Calcitriol receptor
* GPS2,〔〔〔
* Glucocorticoid receptor,
* HDAC3,〔〔〔〔〔
* HDAC4,〔〔
* HDAC7A,
* HDAC9,
* HEY2,
* Histone deacetylase 5,
* MAP3K7IP2,
* MECP2,
* Peroxisome proliferator-activated receptor alpha,
* Promyelocytic leukemia protein,
* RUNX1T1,
* Retinoic acid receptor alpha,〔
* Retinoic acid receptor gamma,〔
* SAP30,〔
* TBL1XR1,〔
* TBL1X,〔〔 and
* ZBTB33.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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