翻訳と辞書 Words near each other ・ N-Joypad ・ N-linked glycosylation ・ N-localizer ・ N-malonylurea hydrolase ・ N-methyl nucleosidase ・ N-methyl-2-oxoglutaramate hydrolase ・ N-Methyl-2-pyrrolidone ・ N-Methyl-3-piperidyl benzilate ・ N-Methyl-D-aspartic acid ・ N-methyl-L-amino-acid oxidase ・ N-Methyl-L-glutamic acid ・ N-Methyl-N-ethyltryptamine ・ N-Methyl-PPPA ・ N-methylalanine dehydrogenase ・ N-Methylaniline ・ N-Methylcarfentanil ・ N-methylcoclaurine 3'-monooxygenase ・ N-Methylconiine ・ N-Methylephedrine ・ N-Methylethanolamine ・ N-Methylformamide ・ N-methylhydantoinase (ATP-hydrolysing) ・ N-Methylhydroxylamine ・ N-Methylmaleimide ・ N-Methylmescaline ・ N-Methylmorpholine ・ N-Methylmorpholine N-oxide ・ N-Methylornithine ・ N-Methylphenethylamine ・ N-methylphosphoethanolamine cytidylyltransferase Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク N-Methylcarfentanil ： ウィキペディア英語版 N-Methylcarfentanil ''N''-Methylcarfentanil (R-32395) is an opioid analgesic drug related to the highly potent animal tranquilizer carfentanil, but several thousand times weaker, being only slightly stronger than morphine. It was first synthesised by a team of chemists at Janssen Pharmaceutica led by Paul Janssen, who were investigating the structure-activity relationships of the fentanyl family of drugs. They found that replacing the phenethyl group attached to the piperidine nitrogen of fentanyl with a smaller methyl group, made it so much weaker that it was inactive as an analgesic in animals. However the same change made to the more potent analogue carfentanil retained reasonable opioid receptor activity, reflecting the higher binding affinity produced by the 4-carbomethoxy group.〔Dukhovich FS, Darkhovskii MB, Gorbatova EN, Kurochkin VK. Molecular recognition: pharmacological aspects. 2004, Nova Science Publishers, New York. p 81. ISBN 1-59033-887-1〕 Side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear. ==References== 〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「N-Methylcarfentanil」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.