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|Section2= |Section3= }} ''N''-Nitrosonornicotine (NNN) is a tobacco-specific nitrosamine produced during the curing and processing of tobacco. It has been classified as a Group 1 carcinogen.〔(【引用サイトリンク】 Agents Classified by the IARC Monographs, Volumes 1–105 )〕 Although no adequate studies of the relationship between exposure to NNN and human cancer have been reported, there is sufficient evidence that NNN causes cancer in experimental animals. NNN is found in a variety of tobacco products including smokeless tobacco like chewing tobacco and snuff, cigarettes, and cigars. It is present in smoke from cigars and cigarettes, in the saliva of people who chew betel quid with tobacco, and in the saliva of oral-snuff users. NNN is produced by the nitrosation of nornicotine during the curing, aging, processing, and smoking of tobacco. Roughly half of the NNN originates in the unburnt tobacco, with the remainder being formed during burning. NNN can be produced in the acidic environment of the stomach in users of oral nicotine replacement therapies, due to the combination of dietary/endogenous nitrates, and nornicotine(either present as a minor metabolite of nicotine, or as an impurity in the product). Levels found in urine are over an order of magnitude less than when tobacco is consumed, but this remains a potential source of cancer when used in the long term.〔http://www.fda.gov/downloads/Drugs/NewsEvents/UCM232146.pdf〕 == References == 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「N-Nitrosonornicotine」の詳細全文を読む スポンサード リンク
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