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| N-phenethylnormorphine ： ウィキペディア英語版 |
N-Phenethylnormorphine
''N''-Phenethylnormorphine is an opioid analgesic drug derived from morphine by replacing the ''N''-methyl group with β-phenethyl. It is around eight to fourteen times more potent than morphine as a result of this modification, in contrast to most other N-substituted derivatives of morphine, which are substantially less active, or act as antagonists. Binding studies have helped to explain the increased potency of N-phenethylnormorphine, showing that the phenethyl group extends out to reach an additional binding point deeper inside the mu opioid receptor cleft, analogous to the binding of the phenethyl group on fentanyl.
==See also==
* 14-Cinnamoyloxycodeinone
* 14-Phenylpropoxymetopon
* 7-PET
* MR-2096
* ''N''-Phenethyl-14-ethoxymetopon
* ''N''-Phenethylnordesomorphine
* Phenomorphan
* RAM-378
* Ro4-1539
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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