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NACHT, LRR and PYD domains-containing protein 3 (NALP3) also known by cryopyrin is a protein that in humans is encoded by the ''NLRP3'' gene located on the long arm of chromosome 1. NALP3 is expressed predominantly in macrophages and as a component of the inflammasome, detects products of damaged cells such as extracellular ATP and crystalline uric acid. Activated NALP3 in turn triggers an immune response. Mutations in the NLRP3 gene are associated a number of organ specific autoimmune diseases. == Nomenclature == NACHT, LRR, and PYD are respectively acronyms for: * NACHT – NAIP (neuronal apoptosis inhibitor protein), C2TA [class 2 transcription activator, of the MHC, HET-E (heterokaryon incompatibility) and TP1 (telomerase-associated protein 1) * LRR – "leucine-rich repeat" and is synonymous with NLR, for '' or ''nucleotide-binding domain, leucine-rich repeat" * PYD – "PYRIN domain," after the ''pyrin'' proteins The ''NLRP3'' gene name abbreviates "NLR family, pyrin domain containing 3," where NLR refers to "nucleotide-binding domain, leucine-rich repeat." The NACHT, LRR and PYD domains-containing protein 3 is also called: * cold induced autoinflammatory syndrome 1 (CIAS1), * caterpiller-like receptor 1.1 (CLR1.1), and * PYRIN-containing APAF1-like protein 1 (PYPAF1). 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「NALP3」の詳細全文を読む スポンサード リンク
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