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25I-NBOMe
25I-NBOMe (2C-I-NBOMe, Cimbi-5, also shortened to "25I") is a psychedelic drug and derivative of the substituted phenethylamine psychedelic 2C-I. It was discovered in 2003 by chemist Ralf Heim at the Free University of Berlin, who published his findings in his PhD dissertation. The compound was subsequently investigated by a team at Purdue University led by David Nichols.
The carbon-11 labelled version of 25I-NBOMe, ()Cimbi-5, was synthesized and validated as a radiotracer for positron emission tomography (PET) in Copenhagen.〔Hansen, M. (2011).(Design and Synthesis of Selective Serotonin Receptor Agonists for Positron Emission Tomography Imaging of the Brain. ) PhD Thesis, University of Copenhagen.〕 Being the first 5-HT2A receptor full agonist PET radioligand, ()-CIMBI-5 shows promise as a more functional marker of these receptors, particularly in their high affinity states.〔
== Chemistry and structure ==
Like other 2C-''X''-NBOMe molecules, 25I-NBOMe is a derivative of the 2C family of phenethylamines described by Alexander Shulgin in his book PiHKAL.〔 Specifically, 25I-NBOMe is an ''N''-benzyl derivative of the phenethylamine molecule 2C-I, formed by adding a 2-methoxybenzyl (BnOMe) onto the nitrogen (N) of the phenethylamine backbone. This substitution significantly increases the potency of the molecule.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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