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Neutral cholesterol ester hydrolase 1 (NCEH) also known as arylacetamide deacetylase-like 1 (AADACL1) or KIAA1363 is an enzyme that in humans is encoded by the ''NCEH1'' gene. NCEH is an enzyme located in the endoplasmic reticulum. NCEH hydrolyzes 2-acetyl monoalkylglycerol ether, as part of an enzymatic pathway regulating the levels of platelet activating factor and lysophospholipids that may be involved in cancer development. == Function == The enzymatic reaction catalyzed by NCEH is:〔 * 2-acetyl monoalkylglycerol ether → monoalkylglycerol ether Monoalkylglycerol ethers (MAGEs) can then be converted to lysophospholipids alkyl-lysophosphatidic acid (alkyl-LPA) and alkyl-lysophosphatidylcholine (alkyl-LPC). Controversial studies by one group also implicate the protein in the hydrolysis of cholesterol esters. However, loss of the protein in mice selectively reduces 2-acetyl monoalkylglycerol ether activity throughout the body.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「NCEH1」の詳細全文を読む スポンサード リンク
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